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How do you wean off proton pump inhibitors? Folks who have been taking PPIs for a period of six months might consider tapering down their dose instead of stopping cold turkey. However, you might be wondering how to properly taper down. Try to reduce your dose by 50% every week. Once you are on the lowest dose for one full week, you can try stopping your PPI.
How long is long term use of PPI? The long - term safety of PPIs is not completely known. There are 5 PPIs on the US market. Clinical experience with these medications ranges from 3 to 20 years. All of the identified studies addressing long - term use have follow-up of 10 years or less (Table).
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